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Multiple Sclerosis

Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial

Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo-controlled, crossover study

Cannabinoid-induced effects on the nociceptive system: a neurophysiological study in patients with secondary progressive multiple sclerosis

Oromucosal Delta-9–tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial

Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis

Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial

Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis

Cannabis use in patients with multiple sclerosis

Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up

Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients

Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy. Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study

An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis

Randomized controlled trial of cannabis-based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis

Cannabis use as described by people with multiple sclerosis

Safety, tolerability, and efficacy of orally administered cannabinoids in MS

Delta-9-THC in the treatment of spasticity associated with multiple sclerosis

Parkinson’s Disease 

Cannabis and Parkinson’s disease

Enhancing activity of marijuana-like chemicals in the brain helps treat Parkinson’s symptoms in mice, Stanford study finds

Marijuana-like substance in thebrain could help treat Parkinson’s, researchers say

Study: Cannabidiol (CBD) May Help to Prevent or Treat Neurodegenerative Diseases

Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study

Smoking Pot Eases Tremors in Parkinson’s

Finally, some cannabis research worth waiting for…

Studies Show Cannabis Relieves Symptoms of Parkinson’s Disease

Medical Marijuana and Parkinson’s Disease

Survey on Cannabis Use in Parkinson’s Disease: Subjective Improvement of Motor Symptoms: Paper read at 2003 Symposium on the Cannabinoids, at Cornwall, ON, Canada.

Abstract: An anonymous questionnaire sent to all patients attending the Prague Movement Disorder Centre revealed that 25% of 339 respondents had taken cannabis, and 45.9% of these described some form of benefit.

Pertinent References: Venderova, K., E. Ruzicka, V. Vorisek, and P. Visnovsky. 2003.

Cannabis and Parkinson’s disease: Subjective improvement of symptoms and levodopa-induced dyskinesia.

Paper read at 2003 Symposium on the Cannabinoids, at Cornwall, ON, Canada.

Russo, E. Neuroprotection/Degenerative Diseases

Consroe, P. 1998. Brain cannabinoid systems as targets for the therapy of neurological disorders. Neurobiol Dis 5 (6 Pt B):534-51.

Frankel, J. P., A. Hughes, A. J. Lees, and G. M. Stern. 1990. Marijuana for parkinsonian tremor. J Neurol Neurosurg Psychiatry 53 (5):436.

Glass, M. 2001. The role of cannabinoids in neurodegenerative diseases. Prog Neuropsychopharmacol Biol Psychiatry 25 (4):743-65.

Sieradzan, K. A., S. H. Fox, M. Hill, J. P. Dick, A. R. Crossman, and J. M. Brotchie. 2001. Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: a pilot study. Neurology 57 (11):2108-11.

Survey on Cannabis Use in Parkinson’s Disease: Subjective Improvement of Motor Symptoms

Epilepsy 

Marijuana: an effective anti-epileptic treatment in partial epilepsy? A case report and review of the literature

Treatment with CBD in anoily solution of drug-resistant pediatric epilepsies

Anticonvulsant effect of cannabidiol

Chronic administration of cannabidiol to healthy volunteers and epileptic patients

Anticonvulsant nature of marihuana smoking

Neuropathic Pain

Cannabinoid-opioid interaction in chronic pain

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain

Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia

Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial

A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain

Open-label, add-on study of tetrahydrocannabinol for chronic nonmalignant pain

Oromucosal delta-9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial

[Topical cannabinoid agonists: An effective new possibility for treating chronic pruritus.] [Article in German]

Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomized controlled trial

Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 ‘N of 1’ studies

Efficacy of two cannabis-based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomized controlled trial

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial

Cannabis use for chronic non-cancer pain: results of a prospective survey

The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opioids

Cannabis reduces opioid dose in the treatment of chronic non-cancer pain

Cannabinoid agonists attenuate capsaicin-induced responses in human skin

Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%

HIV/AIDS

Marijuana Effectiveness as an HIV Self-Care Strategy

THC improves appetite and reverses weight loss in AIDS patients

Marijuana use and its association with adherence to antiretroviral therapy among HIV-infected persons with moderate to severe nausea

Patterns of marijuana use among patients with HIV/AIDS followed in a public healthcare setting

Differential Effects of Medical Marijuana Based on Strain and Route of Administration: A Three-Year Observational Study

A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men

Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial

Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial

Amyotrophic Lateral Sclerosis (ALS)

An Overview of Amyotrophic Lateral Sclerosis (ALS) Studies with Medical Marijuana

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications and a call for clinical trials

Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomized, double-blind crossover trial

Spinal Cord Damage

A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms

The treatment of spasticity with D9-tetrahydrocannabinol (D9-THC) in patients with spinal cord injury

Clinical investigation of delta-9-tetrahydrocannabinol (THC) as an alternative therapy for overactive bladders in spinal cord injury (SCI) patients

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial

Cannabis effect on spasticity in spinal cord injury

The perceived effects of marijuana on the spinal cord injured males

Inflammatory Bowel Disease

Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study

Cannabis use amongst patients with inflammatory bowel disease

Treatment of Crohn’s disease with cannabis: an observational study

Crohn’s Disease/Ulcerative Colitis Case Reports, Surveys Cannabis

Lal S, Prasad N, Ryan M, Tangri S, Silverberg MS, Gordon A, Steinhart H. Cannabis use amongst patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol 2011;23(10):891-6.

Uncontrolled Studies Cannabis

Naftali T, Lev LB, Yablekovitz D, Half E, Konikoff FM. Treatment of Crohn’s disease with cannabis: an observational study. Isr Med Assoc J 2011;13(8):455-8.

Cancer

A Double-Blind, Placebo-Controlled, Crossover Pilot Trial with Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced Neuropathic Pain

Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting

A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme

Effects of smoked cannabis and oral delta-9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials

An efficient new cannabinoid antiemetic in pediatric oncology

A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia

Marijuana as antiemetic medicine: a survey of oncologists’ experiences and attitudes

Inhalation marijuana as an antiemetic for cancer chemotherapy

Huntington’s Disease

An Overview of Huntington’s Disease and Cannabis

THC for Huntington’s Disease? CB1 receptors are important for more than drug use

Smoking marijuana doesn’t have to be a bad thing – Especially if you have HD